A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease
نویسنده
چکیده
From the David Geffen School of Medicine at the University of California, Los Angeles (D.P.T.); Caritas St. Elizabeth’s Medical Center, Boston (B.C.); Glasgow University, Glasgow, Scotland (S.S.); Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT (D.B., S.K., S.M.); and the University of Leuven, Leuven, Belgium (M.D.). Address reprint requests to Dr. Tashkin at the David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095-1690, or at dtashkin@mednet. ucla.edu.
منابع مشابه
A 4-year trial of tiotropium in chronic obstructive pulmonary disease (UPLIFT trial).
BACKGROUND Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy. METHODS In this randomized, double-blind trial, we compared 4 years of therapy with either tiotropium or placebo in patients with COPD who were permitted to use all respiratory medications ...
متن کاملFour-year trial of tiotropium in chronic obstructive pulmonary disease.
Type of article and design This trial, referred to as the Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT) trial, was a 4-year, randomized, double-blind, placebo-controlled, parallel-group trial involving patients with moderate to very severe COPD. The primary end points included the yearly rate of decline in mean FEV1 before the use of tiotropium and short-acting ...
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Introduction: The long-acting anticholinergic Tiotropium, which used in the treatment of patients with chronic obstructive pulmonary disease, prescribed once a day, unlike other bronchodilators that used several times a day for patients. The study was a systematic review that examined the effectiveness and safety of β2 Agonists and Tiotropium in the patients with chronic obstructive pulmon...
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BACKGROUND Tiotropium Safety and Performance in Respimat® (TIOSPIR®) compared the safety and efficacy of tiotropium Respimat® and tiotropium HandiHaler® in patients with chronic obstructive pulmonary disease (COPD). A prespecified spirometry substudy compared the lung function efficacy between treatment groups. METHODS TIOSPIR® was a large-scale, long-term (2.3-year), event-driven, randomized...
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INTRODUCTION Among patients with chronic obstructive pulmonary disease (COPD), the frequency and severity of past exacerbations potentiates future events. The impact of current therapies on exacerbation frequency and severity in patients with different exacerbation risks is not well known. METHODS A post hoc analysis of patients at low (≤1 exacerbation [oral steroids/antibiotics requirement] ...
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BACKGROUND Although combination therapy with bronchodilators is recommended for chronic obstructive pulmonary disease (COPD), there is insufficient evidence for the efficacy of some combinations of long-acting bronchodilators. OBJECTIVE We investigated the effects of a combination therapy with tiotropium and theophylline in COPD patients. METHODS In a 12-week, open-labeled, parallel-group r...
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